Variations in cortical folding patterns are related to individual differences in temperament

S Whittle; NB Allen; A Fornito; DI Lubman; JG Simmons; C Pantelis; M Yücel

Journal article

Variations in cortical folding patterns are related to individual differences in temperament

S Whittle, NB Allen, A Fornito, DI Lubman, JG Simmons, C Pantelis, M Yücel

Psychiatry Research Neuroimaging | ELSEVIER IRELAND LTD | Published : 2009

DOI: 10.1016/j.pscychresns.2008.06.005

Abstract

There is evidence that anterior cingulate cortex (ACC) function is related to individual differences in temperament. An important question regards how early such brain-behavior associations emerge. We examined the relationship between cortical folding patterns of the ACC, which are functionally relevant and primarily determined by birth, and individual differences in four core temperament dimensions (Effortful Control, Negative Affectivity, Surgency, and Affiliation). Magnetic resonance imaging was used to classify 153 (81 male) early adolescents as displaying a leftward asymmetric, rightward asymmetric, or symmetric pattern of ACC folding, as indexed by the incidence and extent of the parac..

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University of Melbourne Researchers

Sarah Whittle Author

Nick Allen Author

Julian Simmons Author

Christos Pantelis Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by ORYGEN Research Centre, the Colonial Foundation and National Health and Medical Research Council (NHMRC) of Australia Program Grant (I.D. 350241). Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms Bridget Soulsby at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. Dr Whittle was supported by an Australian Postgraduate Award (APA). Dr Fornito was supported by a JN Peters Fellowship and a NHMRC CJ Martin Fellowship (I.D. 454797). Dr Yucel is supported by a NHMRC Clinical Career Development Award (I.D. 509345). The authors would like to thank the Brain Research Institute for support in acquiring the neuroimaging data.